Question

1. (30 points total; 3 points each) (a) Insertion of [which amino acid's] sidechains into the minor groove of a nucleic acid serve as an important feature of protein-nucleic acid recognition. (b) Proteins can distinguish between dsRNA and dsDNA via differences in shape. (c) Name a structural feature that can be used to amplify specificity in peptide-protein interactions. (d) What computational measurement can be used to assess the proportion of buried region at a protein-protein interface? (e) Which of the following is not a known allosteric effector of Hgb: oxygen, bisphosphoglycerate, low pH, myoglobin, CO?. (f) Proteins can distinguish between dsRNA and dsDNA via differences in shape. (g) The maximum value of the Hill coefficient for a dimeric protein is: . (h) Ultrasensitive response links the log-log binding isotherms for the 1st (low-affinity) and 2nd (high-affinity) states of an allosteric protein by what type of curve? (i)/(j) Name two ways by which specificity can be increased in protein-DNA recognition.

          1. (30 points total; 3 points each)

(a) Insertion of [which amino acid's] ________ sidechains into the minor groove of a nucleic acid serve as an important feature of protein-nucleic acid recognition.

(b) Proteins can distinguish between dsRNA and dsDNA via differences in ________ shape.

(c) Name a structural feature that can be used to amplify specificity in peptide-protein interactions.

(d) What computational measurement can be used to assess the proportion of buried region at a protein-protein interface?

(e) Which of the following is not a known allosteric effector of Hgb: oxygen, bisphosphoglycerate, low pH, myoglobin, CO?.

(f) Proteins can distinguish between dsRNA and dsDNA via differences in ________ shape.

(g) The maximum value of the Hill coefficient for a dimeric protein is: ________.

(h) Ultrasensitive response links the log-log binding isotherms for the 1st (low-affinity) and 2nd (high-affinity) states of an allosteric protein by what type of curve?

(i)/(j) Name two ways by which specificity can be increased in protein-DNA recognition.

1. (30 points total; 3 points each)

(a) Insertion of [which amino acid's] sidechains into the minor groove of a nucleic acid serve as an important feature of protein-nucleic acid recognition.

(b) Proteins can distinguish between dsRNA and dsDNA via differences in shape.

(c) Name a structural feature that can be used to amplify specificity in peptide-protein interactions.

(d) What computational measurement can be used to assess the proportion of buried region at a protein-protein interface?

(e) Which of the following is not a known allosteric effector of Hgb: oxygen, bisphosphoglycerate, low pH, myoglobin, CO?.

(f) Proteins can distinguish between dsRNA and dsDNA via differences in shape.

(g) The maximum value of the Hill coefficient for a dimeric protein is: .

(h) Ultrasensitive response links the log-log binding isotherms for the 1st (low-affinity) and 2nd (high-affinity) states of an allosteric protein by what type of curve?

(i)/(j) Name two ways by which specificity can be increased in protein-DNA recognition.

Added by Cristina J.

Question

Please give Ace some feedback