A critical transition state in serine protease catalysis is the "tetrahedral intermediate". Briefly describe the role played by each member of the catalytic triad in the process of forming the first tetrahedral intermediate.
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The catalytic triad typically consists of three amino acids: Histidine (His), Aspartate (Asp), and Serine (Ser). Each plays a crucial role in the mechanism of catalysis, particularly in the formation of the tetrahedral intermediate. Show more…
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