00:01
Hello, my dear friends.
00:03
The concepts given in the question is about the events in cell cycle and the working of a cell signaling path.
00:19
Okay? yes, this pathway is nothing but p13k or otherwise also called as akt signaling pathway, where we have to find out its link with the working or function.
00:37
Functioning of an inhibitor which is nothing but b21.
00:42
And in cell cycle, we need to find out an event, okay, with respect to the given conditions in the first sub -question.
00:52
So this is what we'll discuss in the first sub -question.
00:54
And about this, we'll be discussed in the second sub -question.
00:58
Yes.
00:58
So i have explained what is required also here is the explaining of the conditions given in sub -question 1 and sub -question 2.
01:10
Now let us get into the explanation.
01:14
Now, my dear friends, what is cell cycle? it is a sequence of stages where duplication of chromosomes and cell content is ensured before the cell.
01:50
Enters mitosis or meiosis, right? yes, okay, this is cell cycle.
02:00
Now, the conditions what they have given is we need to find out an event, okay, which is irreversible, yes, produces viable cells where there is no depth of it, and then are those cells are in non -growing state.
02:24
These are the three conditions with the given options we need to find out which is that event.
02:30
Now the first option they're talking about arrest point.
02:38
The second one talks about senescence.
02:45
Third one talks about quissence.
02:51
Fourth one, okay.
02:54
Talks about inactivation.
02:59
And fifth one talks about inactivation.
03:02
Evolution.
03:05
Okay.
03:06
Now my dear friends, arrest point actually means the checkpoints in a cell cycle where because of certain terminating signals or because of certain, you know, inhibiting signals.
03:22
In fact, at this checkpoint, it checks whether all the conditions are there for duplication of the cell content and chromosome.
03:30
If it is not there, it arrests the cell cycle cycle.
03:34
At the checkpoints.
03:36
So that is what is called as arrest point.
03:38
And this is reversible.
03:42
Okay, just because of the presence of that signal, it actually stops the cell cycle, but it is not irreversible.
03:49
It is reversible.
03:51
Okay.
03:51
Now, as this is reversible, it does not go up with the given condition.
03:55
That's why this is a wrong option.
03:57
Now next is senescence.
03:59
Seneissance talks about the cells which are being matured or have undergone aging.
04:05
Now, these cells get into a stage where they do not show any more growth in the cell content or chromosome.
04:15
So yes, they are in the non -growing state.
04:17
The cells produced by them are not going to die.
04:20
So they're viable and yes, this is irreversible.
04:25
The cell which has entered, you know, the maturity path or it has been aged.
04:31
It cannot be bought back for undergoing division.
04:34
So according to the question, the correct option is senicence.
04:38
Let us do justice with the other options.
04:40
Quisson stage is also called as g0 phase and cell cycle.
04:44
It is a temporary phase or stage where the cell remains in the non -growing stage.
04:54
That means it does not enter cell cycle.
04:57
So the cells of lungs, heart, etc.
05:01
Does not enter cell cycle until and unless there's a required.
05:05
If there is a damage or any kind of rupture, then only to fill that area with the new cells, these cells enter, you know, the g1 phase of cell cycle, otherwise they're in the resting period, okay, which is called as g0 phase...