Question

1. Describe, from fertilization, the major pathways of normal male sex development. Include the stages in which genetic sex, gonadal sex, and phenotypic sex are determined. 2. Discuss whether the following individuals (1) have male or female gonads, (2) are phenotypically male or female (Wolffian or Muellerian ducts, external genitalia), and (3) are sterile or fertile. a) XY, homozygous for a recessive mutation in the testosterone biosynthetic pathway, producing no testosterone. b) XX, heterozygous for a dominant mutation in the testosterone biosynthetic pathway, which causes continuous production of testosterone. 3. Calico cats are almost invariably female. Why? (Hint: explain the genotype and phenotype of calico females) 4. How many Barr bodies would the following individuals have? a) Normal male b) Normal female c) Klinefelter male d) Turner female

          1. Describe, from fertilization, the major pathways of normal male sex development. Include the stages in which genetic sex, gonadal sex, and phenotypic sex are determined.
2. Discuss whether the following individuals (1) have male or female gonads, (2) are phenotypically male or female (Wolffian or Muellerian ducts, external genitalia), and (3) are sterile or fertile.
a) XY, homozygous for a recessive mutation in the testosterone biosynthetic pathway, producing no testosterone.
b) XX, heterozygous for a dominant mutation in the testosterone biosynthetic pathway, which causes continuous production of testosterone.
3. Calico cats are almost invariably female. Why? (Hint: explain the genotype and phenotype of calico females)
4. How many Barr bodies would the following individuals have?
a) Normal male
b) Normal female
c) Klinefelter male
d) Turner female

Added by Ashley R.

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