1. Diagram the hypothalamic-pituitary-thyroid axis. Make sure to include the feedback loops and spell out the hormone names. 2. What is the physiological role of thyroid hormones? Does T3 or T4 play a larger role in the target tissues? Explain. 3. If you gave a person with primary hypothyroidism (iodine deficiency) an injection of TSH, would T3 and T4 levels increase? Why or why not?
Added by Evan P.
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The hypothalamic-pituitary-thyroid axis can be diagrammed as follows: - Hypothalamus releases Thyrotropin-Releasing Hormone (TRH) - TRH stimulates the anterior pituitary gland to release Thyroid-Stimulating Hormone (TSH) - TSH stimulates the thyroid gland to Show more…
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3. Create a flow chart illustrating the relationship between the hypothalamus, the anterior pituitary gland, and the thyroid. You must include the following in your flow chart: thyrotropin releasing hormone, T3/T4, thyroid stimulating hormone. You must also indicate where in this pathway negative feedback control points are located, and which of these hormones is/are responsible for that negative feedback.
Sri K.
1. Draw the hypothalamic-pituitary-thyroid axis, showing negative feedback control points. 2. A TRH stimulation test involves measuring basal TSH levels and then measuring again after an injection of TRH. This test is often not necessary for thyroid patients, but would it be beneficial in diagnosing Barbara's condition? (Barbara has low TSH, T3, T4). 3. Extrapolate the knowledge you have of the hypothalamic-anterior-pituitary-thyroid axis to explain how anabolic steroid abuse would lead to testicular atrophy.
Adi S.
Draw the release pathway for Thyroid hormone under a condition of primary hypothyroidism. Label all glands/structures, name the root cause of the hypothyroidism, name and give relative concentrations of each hormone involved, show negative feedback loop, and indicate if it is active in this scenario, and tell whether a goiter would likely be present or not.
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