Question

1 Essay 3 points Aspartic acid (left) and glutamic acid (right) are both amino acids that are used in synthesis of proteins and other metabolic reactions. Their side chain carboxylic acid gro shown in the box outlines and, respectively, have \( \mathrm{pK}_{3} \) values within the ranges of 3.7-3.9 and 4.1-4.3. This difference makes the highlighted carboxyl group of aspartic aci approximately 3 times as acidic as the carboxyl group in glutamic acid's side chain. Given the structural similarities of these two amino acids, how do you account for the difference between the \( \mathrm{pK}_{2} \) 's of the side chains? Aspartic Acid Glutamic Acid Edit View Insert Format Tools Table \( 12 \mathrm{pt} \sim \) Paraerph \( \quad B I \underline{U} A \vee \sim T^{2} \)

          1
Essay 3 points

Aspartic acid (left) and glutamic acid (right) are both amino acids that are used in synthesis of proteins and other metabolic reactions. Their side chain carboxylic acid gro shown in the box outlines and, respectively, have \( \mathrm{pK}_{3} \) values within the ranges of 3.7-3.9 and 4.1-4.3. This difference makes the highlighted carboxyl group of aspartic aci approximately 3 times as acidic as the carboxyl group in glutamic acid's side chain. Given the structural similarities of these two amino acids, how do you account for the difference between the \( \mathrm{pK}_{2} \) 's of the side chains?

Aspartic Acid

Glutamic Acid

Edit View Insert Format Tools Table
\( 12 \mathrm{pt} \sim \) Paraerph \( \quad B I \underline{U} A \vee \sim T^{2} \)

1
Essay 3 points

Aspartic acid (left) and glutamic acid (right) are both amino acids that are used in synthesis of proteins and other metabolic reactions. Their side chain carboxylic acid gro shown in the box outlines and, respectively, have pK3 values within the ranges of 3.7-3.9 and 4.1-4.3. This difference makes the highlighted carboxyl group of aspartic aci approximately 3 times as acidic as the carboxyl group in glutamic acid's side chain. Given the structural similarities of these two amino acids, how do you account for the difference between the pK2 's of the side chains?

Aspartic Acid

Glutamic Acid

Edit View Insert Format Tools Table
12 pt∼ Paraerph B I U A ∨∼ T^2

Added by Lisa B.

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