1. Expression of selectins triggered by cytokine release. 2. Rolling of leukocytes due to interactions with glycoproteins on the leukocytes and proteins on the blood vessels. 3. Activation of the integrin to a high affinity state by chemokines. 4. Tight binding between the integrin on the leukocyte and a protein on the blood vessel that stops the leukocyte. 5. The leukocyte leaves the blood and enters the inflamed tissue.
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Step 1: Cytokines are released in response to an inflammatory stimulus, triggering the expression of selectins on the endothelial cells lining the blood vessels. Show more…
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