1. Given the high rate of Sickle Cell Disease (SCD) and the fact that treatment early is beneficial, all newborns in the state of New York are screened for SCD; blood samples MUST be taken around 24 hours after the baby is born. You are working in the lab carrying out this diagnosis. Draw the hemoglobin migration patterns you will see for the following three newborns (hint: remember the AGE of these patients when considering which hemoglobins are present): A) 2 copies of the normal -hemoglobin gene. B) Sickle Cell Trait (i.e. is heterozygous). C) Sickle Cell Disease
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Step 1: For the newborn with 2 copies of the normal hemoglobin gene, you would expect to see two clear strands in the hemoglobin migration pattern. Show more…
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Sickle cell disease (SCD) is an autosomal recessive and incompletely dominant disease that is caused by a mutation in a gene that results in a substitution of one amino acid for another when a hemoglobin protein is constructed. The abnormal hemoglobin causes problems with the red blood cells and the health of the person with this mutation. Normal hemoglobin (A) is dominant over sickle cell hemoglobin (a). A man that is a carrier for SCD mates with a woman that does not have SCD and is not a carrier. Complete the one trait cross, including the phenotypes, genotypes, and gametes of the parents, as well as the Punnett Square and genotype and phenotype ratios.
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Sickle cell disease (SCD) is caused by a recessive version of the hemoglobin gene. In the US, SCD occurs in about 0.2% of the newborn babies. In some African countries, 4% of the newborn babies have sickle cell. Out of a random sample of 10,000 newborn babies in the US, how many would you expect to be homozygous for the normal, dominant hemoglobin genotype assuming Hardy Weinberg equilibrium?
A gene is composed of two alleles. An allele can be either dominant or recessive. Suppose a husband and wife, who are both carriers of the sickle-cell anemia allele but do not have the disease, decide to have a child. Because both parents are carriers of the disease, each has one dominant normal-cell allele and one recessive sickle-cell allele. Therefore, the genotype of each parent is $S s .$ Each parent contributes one allele to his or her offspring, with each allele being equally likely. (a) List the possible genotypes of their offspring. (b) What is the probability that the offspring will have sickle-cell anemia? In other words, what is the probability the offspring will have genotype $s s ?$ Interpret this probability. (c) What is the probability that the offspring will not have sickle-cell anemia but will be a carrier? In other words, what is the probability that the offspring will have one dominant normal-cell allele and one recessive sickle-cell allele? Interpret this probability.
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