1. List three functions of the immunologic response. 2. State the two cells lines which are produced once a stem cell is "committed". 3. State the function of the three different types of T-cells. 4. Describe the role of the B cell in the immune response. 5. Compare the "innate" immune response with the "adaptive" immune response. 6. List five physical factors which are part of the innate immune system. 7. Describe the inflammation process. 8. State the four signs/symptoms of inflammation. 9. Define "antigen". 10.List three physical criteria which characterize an antigen. 11.Define the term "antigenic determinants". 12.Describe the chemical structure of blood group antigens. 13.Define "hapten". 14.Compare the cellular immune response with the humoral immune response. 15.Compare the primary and secondary immune response in respect to time, antibody titer, antibody, and class produced. 16.Define the terms affinity and avidity as they relate to antibody production. 17. Identify the following components of an antibody: ○ Heavy chains ○ Light chains ○ Fab portion ○ Fc portion ○ Antigen binding site ○ Disulfide bridges 18.Describe the pieces formed when an antibody is treated with the enzymes papain and pepsin. 19.Describe the characteristics and functions of the five classes of antibodies.
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Adaptive Immunity 1. Name two antigen-presenting cells. What is their role in the adaptive immune system? Which classes of MHC proteins do they express and why is this important? 2. Where do B- and T-cells come from, and where do they mature? 3. How do APC's activate TH cells? 4. How is clonal selection related to the vast number of possible B and T-cell receptor binding conformations? Draw a picture to illustrate your explanation. 5. Why do many diseases such as measles, occur only once in a person - yet others, such as colds, occur more than once? 6. What are the two branches of the adaptive immune system? Which lymphocyte is key in both branches? 7. Describe three ways that Th cells are "helpers". 8. List three different antibody isotypes (immunoglobulin classes) and describe the job of each one. 9. What are three different ways antibodies protect against infectious agents? 10. How does a cytotoxic T-lymphocyte kill a virally infected cell? Use the words "perforin", "granzyme" and "apoptosis" in your answer. 11. What is the difference between T-dependent and T-independent B-cell activation? 12. What is the role of a Treg (regulatory T-cell).
Adi S.
1. What is the function of the immune system? 2. What is the name of the first line of defense in the immune system? Is it specific or non-specific? 3. What is the name of the second line of defense in the immune system? Is it specific or non-specific? 4. What are the two functions of the lymphatic system? 5. What is the name of the fluid that circulates throughout the lymphatic vessels? 6. What is the name of the fluid mentioned in question #5 when it moves into blood vessels? 7. What is another name for a white blood cell? 8. What is a lymphocyte? 9. Name two examples of lymphocytes. 10. What is the function of the macrophages? 11. Which lymphocyte has granules that contain lysosomal enzymes? 12. Which lymphocyte has granules that contain histamine? 13. Which lymphocyte has granules which releases a toxic protein that defends against parasites granules? 14. What is the function of the natural killer cells? 15. What is the function of the helper T cells? 16. What is the function of the cytotoxic T cells? 17. What is the function of the spleen? Where is it located? 18. What is the function of the thymus? Where is it located? 19. What is the function of the lymph nodes? Where are they located?
Madhur L.
3. Describe 3 important functions of the lymphatic system 4. Explain where lymph comes from, its composition and how it returns to the bloodstream 5. Compare and contrast lymph nodes and lymphatic nodules and the spleen in terms of composition, structure, function and location 6. Discuss the thymus. What role does it play in the immune system? 7. Make a chart, table, outline or picture that shows the subdivisions of the immune response. 8. Describe 3 types of first-line immunity and give examples of each 9. Describe, cellular and non-cellular mechanisms (proteins and processes) of second-line immunity 10. Explain the causes of inflammation and fever and explain why they are useful (related to #9) 11. Name 5 types of antibodies, list their functions and describe the concept of antigen-antibody interaction 12. Compare and contrast specific and non-specific immunity
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