Question

Recent evidence indicates that receptors for many types of G-protein coupled receptors (GPRCs) have constitutive (basal) activity independent of ligand activation. In such systems, specific ligands (inverse agonists) can bind to these receptors, producing effects that are opposite to those of a conventional agonist. In the graph below, which drug displays a dose-response relationship consistent with this type of behavior? 100% Muscarinic GPCR Mediated Activity A B C D Constitutive level of activity in absence of drug 0% Log [Drug] Drug B Drug D Drug C Drug A

          Recent evidence indicates that receptors for many types of G-protein coupled receptors (GPRCs) have constitutive (basal) activity independent of ligand activation. In such systems, specific ligands (inverse agonists) can bind to these receptors, producing effects that are opposite to those of a conventional agonist. In the graph below, which drug displays a dose-response relationship consistent with this type of behavior?

100%
Muscarinic GPCR Mediated Activity
A
B
C
D
Constitutive level of activity in absence of drug
0%
Log [Drug]

Drug B
Drug D
Drug C
Drug A

Show more…

Recent evidence indicates that receptors for many types of G-protein coupled receptors (GPRCs) have constitutive (basal) activity independent of ligand activation. In such systems, specific ligands (inverse agonists) can bind to these receptors, producing effects that are opposite to those of a conventional agonist. In the graph below, which drug displays a dose-response relationship consistent with this type of behavior?

100%
Muscarinic GPCR Mediated Activity
A
B
C
D
Constitutive level of activity in absence of drug
0%
Log [Drug]

Drug B
Drug D
Drug C
Drug A

Added by Joel R.

Biology for AP Courses

Julianne Zedalis, John Eggebrecht

Instant Answer

Solved by Expert Madhur L

03/22/2023

Step 1

We have a G-protein coupled receptor (GPCR) with constitutive (basal) activity independent of ligand binding. Show more…

Show all steps

lock

Thanks for your feedback!

For many types of protein-coupled receptors (GPCRs), recent evidence indicates that receptors have constitutive (basal) activity independent of ligand-specific activation. Inverse agonists can bind to these receptors and produce effects that are opposite to those produced by conventional agonists. The drug displays a dose-response relationship consistent with the graph below. Which type of behavior does this graph represent?

Play audio

Feedback

Powered by NumerAI

Madhur L and 54 other subject Biology educators are ready to help you.

Ask a new question

Labs

Want to see this concept in action?

NEW

Explore this concept interactively to see how it behaves as you change inputs.

View Labs

Key Concepts

Recommended Videos

Recommended Textbooks

Transcript

Ace is your personal tutor. It breaks down any question with clear steps so you can learn.

Start Using Ace

Continue solving this problem

Create a free account to:

View full step-by-step solution
Ask follow-up questions with Ace AI
Save progress and study later