Question

1. To give you some idea of how incredibly small condensed chromosomes are, our text points out that if human chromosome 1 were expanded to be as thick as a strand of (cooked) spaghetti, it would stretch for 25 miles (p. 87). Imagine that you've invented a way to make single cells so much larger that a DNA duplex has a diameter of 0.1 mm — about the thickness of a human hair. a. (5 points) If you were to do that, how long a ‘hair’ would there be in a typical human fibroblast (assuming the DNA is not compacted)? Note that I want you to take into account all of the DNA in a typical human nucleus. [Show your calculations here, and be sure to include any information you use about the dimensions of DNA molecules.] b. (5 points) How big would a single cell be? [Be sure to tell me what you think the actual dimensions of a fibroblast are, so that I can properly evaluate your answers here!] c. (5 points) How big would that cell's nucleus be? [Again, be sure to tell me what you think the actual dimensions of the nucleus are, so that I can properly evaluate your answers here!]

          1. To give you some idea of how incredibly small condensed chromosomes are, our text points out that if human chromosome 1 were expanded to be as thick as a strand of (cooked) spaghetti, it would stretch for 25 miles (p. 87). Imagine that you've invented a way to make single cells so much larger that a DNA duplex has a diameter of 0.1 mm — about the thickness of a human hair.

a. (5 points) If you were to do that, how long a ‘hair’ would there be in a typical human fibroblast (assuming the DNA is not compacted)? Note that I want you to take into account all of the DNA in a typical human nucleus. [Show your calculations here, and be sure to include any information you use about the dimensions of DNA molecules.]

b. (5 points) How big would a single cell be? [Be sure to tell me what you think the actual dimensions of a fibroblast are, so that I can properly evaluate your answers here!]

c. (5 points) How big would that cell's nucleus be? [Again, be sure to tell me what you think the actual dimensions of the nucleus are, so that I can properly evaluate your answers here!]

1. To give you some idea of how incredibly small condensed chromosomes are, our text points out that if human chromosome 1 were expanded to be as thick as a strand of (cooked) spaghetti, it would stretch for 25 miles (p. 87). Imagine that you've invented a way to make single cells so much larger that a DNA duplex has a diameter of 0.1 mm — about the thickness of a human hair.

a. (5 points) If you were to do that, how long a ‘hair’ would there be in a typical human fibroblast (assuming the DNA is not compacted)? Note that I want you to take into account all of the DNA in a typical human nucleus. [Show your calculations here, and be sure to include any information you use about the dimensions of DNA molecules.]

b. (5 points) How big would a single cell be? [Be sure to tell me what you think the actual dimensions of a fibroblast are, so that I can properly evaluate your answers here!]

c. (5 points) How big would that cell's nucleus be? [Again, be sure to tell me what you think the actual dimensions of the nucleus are, so that I can properly evaluate your answers here!]

Added by Jose P.

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