10. Consider the base-catalyzed reaction below:
A
OH
OH
1) "OMe
OMe
2) H
OMe
A
B
Which of the following reason is correct with regard to the above reaction
a) compound A is a major product because carbon 2 forms a more stable carbocation
b) Compound B is a major product because carbon 1 forms a more stable carbocation
c) compound A is a major product because Carbon 2 is less hindered
d) compound B is a major product because carbon 1 is less hindered
e) choices a) and c) are correct
SECTION B
1) estrogen is a well know contraceptive for family planning, made from estrone which is a natural
mammalian (animal) hormone.
HO
HO
estrone
estrogen
Mg
estrone
A
R2
OH
Ri
estrogen
OH
a) give structure of compound A
b) give mechanism for the formation of estrogen from compound A and estrone
c) name the reaction on b) above
2. Consider the compounds below
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