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10:17 Back Pharmacokinetics tut.docx Tutorial: pharmacokinetics Consider the following scenario: a drug has a first order elimination rate constant of $0.5hr^{-1}$ and an apparent distribution volume of 3 litres. You wish to maintain a patient's serum levels of this drug above a level of 15mg/litre for as long as possible, but you do not have continuous IV access. Instead, you have access to several IV injections of varying doses; specifically: 2 of 60mg, 2 of 45mg, and 12 of 15mg. What is the longest period that you could maintain the desired serum level for, and what sequence of injections (and at what times) would achieve this? For ongoing decline: $C(t_x) = C(t) * e^{-k*t}$; $t = ln(C(t_x) / C(t)) / (-k)$ For injection: $C(new) = C(old) + I/V_{app}$ Dashboard Calendar To-do Notifications Inbox

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Pharmacokinetics tut.docx
Tutorial: pharmacokinetics
Consider the following scenario: a drug has a first order elimination rate constant of $0.5hr^{-1}$ and an apparent distribution volume of 3 litres. You wish to maintain a patient's serum levels of this drug above a level of 15mg/litre for as long as possible, but you do not have continuous IV access. Instead, you have access to several IV injections of varying doses; specifically: 2 of 60mg, 2 of 45mg, and 12 of 15mg. What is the longest period that you could maintain the desired serum level for, and what sequence of injections (and at what times) would achieve this?
For ongoing decline: $C(t_x) = C(t) * e^{-k*t}$; $t = ln(C(t_x) / C(t)) / (-k)$
For injection: $C(new) = C(old) + I/V_{app}$
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1017 back pharmacokinetics tutdocx tutorial pharmacokinetics consider the following scenario a drug has a first order elimination rate constant of 05hr 1 and an apparent distribution volume 92422

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