15. List three ways in which clotting is limited. 16. Diagram the fibrinolytic system. 17. How does fibrin help initiate the fibrinolytic system?
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The fibrinolytic system is responsible for breaking down blood clots after they have served their purpose. Fibrin is the protein that forms the meshwork of a blood clot. Show more…
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Classify the following statements and characteristics with the appropriate method of clotting prevention: Thrombin at normal blood flow rates Undamaged blood vessels Promote the action of antithrombin Block the action of thrombin on fibrinogen Interfere with the formation of prothrombin activator Deactivate thrombin Prostacyclin Platelet Repulsion Dilution Anticoagulants.
Marlyn J.
Match the following (an answer may be used more than once): _____1. causes platelets to aggregate in feedback fashion _____2. activates prothrombin _____3. fibrinolytic enzyme _____4. inhibits platelet aggregation ____5. first factor activated in intrinsic clotting pathway ____6. forms meshwork of the clot ____7. stabilizes the clot ____8. activates fibrinogen ____9. activated by tissue thromboplastin (a) prostacyclin (b) plasmin (c) ADP (d) fibrin (e) thrombin (f) factor $X$ (g) factor XII (h) factor XIII
Sri K.
Complete It: Clot Retraction and Thrombolysis Fill in the blanks to complete the following paragraphs that describe clot retraction and fibrinolysis. At the end of the coagulation cascade, when the platelet plug has formed and the threads glue the platelet plug together, the fibers in the platelets contract. This action, called clot retraction, brings the edges of the vessel closer together. It also squeezes out serum from the clot, which contains plasma without clotting factors. When the wounded vessel has healed, the clot is removed by the process of thrombolysis. The first step of this process is to break down fibrin by the process of fibrinolysis. It begins when endothelial cells release tissue plasminogen activator (tPA), which catalyzes the conversion of plasminogen to the active enzyme plasmin. This enzyme then degrades fibrin, which causes the clot to dissolve. Key Concept: It is obviously important to clot a broken blood vessel. Why is it equally important to eventually break down that clot?
Adi S.
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