2. A 66-year-old man is brought to the emergency department because of a 1-day history of fever. He underwent transurethral resection of the prostate 1 week ago. His temperature is 39.5°C (103°F), and blood pressure is 75/40 mm Hg. Physical examination shows no other abnormalities. Blood cultures grow lactose-positive, gram-negative rods. Which of the following best describes the initial event in the development of hypotension in this patient? • A) Hemolysin lysis of erythrocytes • B) Induction of histamine release • C) Invasion of segmented neutrophils • D) Lipopolysaccharide stimulation of toll-like receptor • E) Toxic activity of an ADP ribosyltransferase
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Septic shock is characterized by a systemic inflammatory response (eg, fever, tachycardia, tachypnea) and hypotension that persists despite adequate fluid resuscitation. The initial event in the development of septic shock from gram-negative bacteria is the Show more…
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