2. Explain in detail Mitchell's chemiosmotic theory of oxidative phosphorylation and outline 4 examples of experimental evidence that led to the widespread acceptance of this theory. Note: a schematic of the electron transport chain (ETC) is provided in Appendix 1 to aid your answer. You do NOT need to outline all the steps involved in the ETC.
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Electrons from NADH and FADH2 are passed down the electron transport chain (ETC), embedded in the inner mitochondrial membrane. This electron transport is coupled to the pumping of protons ($H^+$) from the mitochondrial matrix to the intermembrane space, Show more…
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Peter Mitchell won the Nobel Prize for his work on the Chemiosmotic Theory. The Chemiosmotic Theory was a critical step in figuring out how oxidative phosphorylation worked for which of the following reasons? Hint: Think about what these experiments showed: It established that the proton gradient was the link between the electron transport chain and ATP synthesis. It established that oxygen was the final electron acceptor at the end of the electron transport chain. It established that there were multiple points of entry for electrons into the electron transport chain. It established that ATP synthase had two parts: the F1 fragment and the FO fragment.
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