2 This complex of three enzymes converts pyruvate into acetyl-CoA (2). 12 The loss of TPP causes this medical condition. 13 This 'cousin' of NAD is found internally on E3 of PDH. 15 When a carbon compound gains an extra electron to gain a charge. 16 Rising levels of \_\_\_\_\_\_\_\_ stimulates PDH. 17 Isocitrate dehydrogenase is allosterically activated by \_\_\_\_\_\_\_\_.
Added by Dustin R.
Close
Step 1
We need to determine the missing words based on our knowledge of biochemistry. Show more…
Show all steps
Your feedback will help us improve your experience
Dominador Tan and 54 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
A) Escherichia coli mutants that lack dihydrolipoamide dehydrogenase (E3) cannot grow on glucose unless they are supplemented with two additional compounds. Can you predict what those compounds are? - Isocitrate and citrate - Glyoxylate and malate - Lipoic acid and pyruvate - α-ketoglutarate and fumarate - Acetate and succinate B) Which of the following metabolites would you expect to be elevated in the bloodstream of an individual suffering from thiamine deficiency (beriberi)? - Glucose. - Pyruvate. - Acetyl-CoA. - Citrate. - Oxaloacetate. C) Which TCA cycle enzyme differs from all others in its cellular location? - Citrate synthase. - Aconitase. - α-ketoglutarate dehydrogenase. - Succinyl-CoA synthetase. - Succinate dehydrogenase. D) What is the role of anaplerotic reactions? - To replenish TCA cycle intermediates which are being consumed in anabolic pathways. - To allow acetate derived from fatty acids to be used as a carbon source. - To bypass NADH generating reactions of the TCA cycle and so to facilitate redox balancing. - To allow glyoxylate to be used as a carbon source. - They are oxidative decarboxylations that lead to production of CO2. E) Anaplerotic reactions 'fix' carbon to increase the concentration of citric acid cycle intermediates. Where does this extra carbon come from? - Glycogen. - Pyruvate. - Acetyl-CoA. - Fatty acids. - CO2.
Dominador T.
33. Which of the following is a coenzyme of pyruvate dehydrogenase? A) TPP B) hydroxyethyl-TPP C) acetyl-CoA D) pyruvate E) NAD+ F) FAD G) lipoamide 34. Which of the following is a substrate of pyruvate dehydrogenase? A) TPP B) hydroxyethyl-TPP C) acetyl-CoA D) pyruvate E) NAD+ F) FAD G) lipoamide 35. Which of the following is a substrate of dihydrolipoyl dehydrogenase? A) TPP B) hydroxyethyl-TPP C) acetyl-CoA D) pyruvate E) NAD+ F) FAD G) lipoamide
Sri K.
Pyruvate dehydrogenase is a large, highly integrated complex containing many copies of three distinct enzymes. There are five coenzymes involved in its catalytic activity: NAD+, FAD, coenzyme A, lipoamide, and thiamine pyrophosphate (TPP or TDP). The coenzymes can be classified depending on how they participate in an enzymatic reaction: A coenzyme prosthetic group is tightly bound to the enzyme and remains bound during the catalytic cycle. The original coenzymes are regenerated during the catalytic cycle. On the other hand, a coenzyme cosubstrate is loosely bound to an enzyme and dissociates in an altered form as part of the catalytic cycle. Its original form is regenerated not by the cycle, but by another enzyme. Which are coenzyme prosthetics? TPP or TDP NAD+ FAD lipoamide coenzyme A
Shaiju T.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD