Question

23. Catabolism of dATP requires adenosine deaminase to remove the amino group to form hypoxanthine. Adenosine deaminase deficiency (ADA) may cause the following except for: a). accumulation of dATP, which allosterically inhibits ribonucleotide reductase activity b). accumulation of adenosine, which inhibits purine biosynthesis and reduces level of guanidine c). lack of other dNTPs blocks T/B cell proliferation in response to microbial infection, causing severe combined immune deficiency (SCID) syndrome d). accumulated dATP forms crystals, damaging joints, causing gout. 24. About metabolites in TCA cycle, which statement is NOT correct? a). fumarate can be used to synthesize heme and Co-Q b). citrate can be transported to cytosol for biosynthesis of fatty acids and cholesterol c). oxaloacetate can be removed from the cycle to generate phosphoenolpyruvate, aspartate and asparagine d). ?-ketoglutarate can be used to synthesize glutamate and glutamine 25. The regulatory enzyme in the biosynthesis of cholesterol is: a). malonyl CoA kinase b). acetyl CoA carboxylase c). HMG-CoA synthase d). HMG-CoA reductase 26. Which of the following carbon sources is not anaplerotic: a). glutamate and glutamine from breakdown of proteins b). fumarate from the breakdown of arginosuccinate in urea cycle c). leucine absorbed from blood stream d). carbon skeleton from the degradation of pyrimidine 27. Ribonucleotide reductase complex reduces NTPs to dNTPs. This reduction takes place by removal of one oxygen atom from a hydroxyl group linked to the ribose ring. The carbon position of this reduction is: a). C1 b). C2 c). C3 d). C4 28. TCA cycle usually is stimulated by an increase of the following factors, EXCEPT for: a). AMP b). ADP c). NADH d). calcium 29. PKU (phenylketonuria) is a metabolic disorder caused by genetic defect impairing the breakdown of: a). phenol b). phenylalanine c). tyrosine d). tryptophan 30. About thiamine pyrophosphate (TPP), which of following statements is INCORRECT? a). required for transaldolase activity b). required for transketolase activity c). required for ?-ketoglutarate dehydrogenase complex d). required for pyruvate dehydrogenase complex 31. Biomolecules that can be derived from phenylalanine include the following, except for: a). GABA b). dopamine c). DOPA d). epinephrine 32. The rate limiting step of fatty acid biosynthesis is: a). citrate cleavage b). acetyl CoA carboxylation

          23. Catabolism of dATP requires adenosine deaminase to remove the amino group to form hypoxanthine. Adenosine deaminase deficiency (ADA) may cause the following except for:
a). accumulation of dATP, which allosterically inhibits ribonucleotide reductase activity
b). accumulation of adenosine, which inhibits purine biosynthesis and reduces level of guanidine
c). lack of other dNTPs blocks T/B cell proliferation in response to microbial infection, causing severe combined immune deficiency (SCID) syndrome
d). accumulated dATP forms crystals, damaging joints, causing gout.

24. About metabolites in TCA cycle, which statement is NOT correct?
a). fumarate can be used to synthesize heme and Co-Q
b). citrate can be transported to cytosol for biosynthesis of fatty acids and cholesterol
c). oxaloacetate can be removed from the cycle to generate phosphoenolpyruvate, aspartate and asparagine
d). ?-ketoglutarate can be used to synthesize glutamate and glutamine

25. The regulatory enzyme in the biosynthesis of cholesterol is:
a). malonyl CoA kinase
b). acetyl CoA carboxylase
c). HMG-CoA synthase
d). HMG-CoA reductase

26. Which of the following carbon sources is not anaplerotic:
a). glutamate and glutamine from breakdown of proteins
b). fumarate from the breakdown of arginosuccinate in urea cycle
c). leucine absorbed from blood stream
d). carbon skeleton from the degradation of pyrimidine

27. Ribonucleotide reductase complex reduces NTPs to dNTPs. This reduction takes place by removal of one oxygen atom from a hydroxyl group linked to the ribose ring. The carbon position of this reduction is:
a). C1 b). C2 c). C3 d). C4

28. TCA cycle usually is stimulated by an increase of the following factors, EXCEPT for:
a). AMP b). ADP c). NADH d). calcium

29. PKU (phenylketonuria) is a metabolic disorder caused by genetic defect impairing the breakdown of:
a). phenol b). phenylalanine c). tyrosine d). tryptophan

30. About thiamine pyrophosphate (TPP), which of following statements is INCORRECT?
a). required for transaldolase activity
b). required for transketolase activity
c). required for ?-ketoglutarate dehydrogenase complex
d). required for pyruvate dehydrogenase complex

31. Biomolecules that can be derived from phenylalanine include the following, except for:
a). GABA b). dopamine c). DOPA d). epinephrine

32. The rate limiting step of fatty acid biosynthesis is:
a). citrate cleavage b). acetyl CoA carboxylation

23. Catabolism of dATP requires adenosine deaminase to remove the amino group to form hypoxanthine. Adenosine deaminase deficiency (ADA) may cause the following except for:
a). accumulation of dATP, which allosterically inhibits ribonucleotide reductase activity
b). accumulation of adenosine, which inhibits purine biosynthesis and reduces level of guanidine
c). lack of other dNTPs blocks T/B cell proliferation in response to microbial infection, causing severe combined immune deficiency (SCID) syndrome
d). accumulated dATP forms crystals, damaging joints, causing gout.

24. About metabolites in TCA cycle, which statement is NOT correct?
a). fumarate can be used to synthesize heme and Co-Q
b). citrate can be transported to cytosol for biosynthesis of fatty acids and cholesterol
c). oxaloacetate can be removed from the cycle to generate phosphoenolpyruvate, aspartate and asparagine
d). ?-ketoglutarate can be used to synthesize glutamate and glutamine

25. The regulatory enzyme in the biosynthesis of cholesterol is:
a). malonyl CoA kinase
b). acetyl CoA carboxylase
c). HMG-CoA synthase
d). HMG-CoA reductase

26. Which of the following carbon sources is not anaplerotic:
a). glutamate and glutamine from breakdown of proteins
b). fumarate from the breakdown of arginosuccinate in urea cycle
c). leucine absorbed from blood stream
d). carbon skeleton from the degradation of pyrimidine

27. Ribonucleotide reductase complex reduces NTPs to dNTPs. This reduction takes place by removal of one oxygen atom from a hydroxyl group linked to the ribose ring. The carbon position of this reduction is:
a). C1 b). C2 c). C3 d). C4

28. TCA cycle usually is stimulated by an increase of the following factors, EXCEPT for:
a). AMP b). ADP c). NADH d). calcium

29. PKU (phenylketonuria) is a metabolic disorder caused by genetic defect impairing the breakdown of:
a). phenol b). phenylalanine c). tyrosine d). tryptophan

30. About thiamine pyrophosphate (TPP), which of following statements is INCORRECT?
a). required for transaldolase activity
b). required for transketolase activity
c). required for ?-ketoglutarate dehydrogenase complex
d). required for pyruvate dehydrogenase complex

31. Biomolecules that can be derived from phenylalanine include the following, except for:
a). GABA b). dopamine c). DOPA d). epinephrine

32. The rate limiting step of fatty acid biosynthesis is:
a). citrate cleavage b). acetyl CoA carboxylation

Added by Carl S.

Biology for AP Courses

Julianne Zedalis, John Eggebrecht

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Solved by Expert Madhur L

01/30/2023

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What is the name of the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to dATP? Show more…

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23. Catabolism of dATP requires adenosine deaminase to remove the amino group to form hypoxanthine. Adenosine deaminase deficiency (ADA) may cause the following except for: a). accumulation of dATP, which allosterically inhibits ribonucleotide reductase activity b). accumulation of adenosine, which inhibits purine biosynthesis and reduces level of guanidine c). lack of other dNTPs blocks T/B cell proliferation in response to microbial infection, causing severe combined immune deficiency (SCID) syndrome d). accumulated dATP forms crystals, damaging joints, causing gout. 24. About metabolites in TCA cycle, which statement is NOT correct? a). fumarate can be used to synthesize heme and Co-Q b). citrate can be transported to cytosol for biosynthesis of fatty acids and cholesterol c). oxaloacetate can be removed from the cycle to generate phosphoenolpyruvate, aspartate and asparagine d). ̑-ketoglutarate can be used to synthesize glutamate and glutamine 25. The regulatory enzyme in the biosynthesis of cholesterol is: a). malonyl CoA kinase b). acetyl CoA carboxylase c). HMG-CoA synthase d). HMG-CoA reductase 26. Which of the following carbon sources is not anaplerotic: a). glutamate and glutamine from breakdown of proteins b). fumarate from the breakdown of arginosuccinate in urea cycle c). leucine absorbed from blood stream d). carbon skeleton from the degradation of pyrimidine 27. Ribonucleotide reductase complex reduces NTPs to dNTPs. This reduction takes place by removal of one oxygen atom from a hydroxyl group linked to the ribose ring. The carbon position of this reduction is: a). C1 b). C2 c). C3 d). C4 28. TCA cycle usually is stimulated by an increase of the following factors, EXCEPT for: a). AMP b). ADP c). NADH d). calcium 29. PKU (phenylketonuria) is a metabolic disorder caused by genetic defect impairing the breakdown of: a). phenol b). phenylalanine c). tyrosine d). tryptophan 30. About thiamine pyrophosphate (TPP), which of following statements is INCORRECT? a). required for transaldolase activity b). required for transketolase activity c). required for ̑-ketoglutarate dehydrogenase complex d). required for pyruvate dehydrogenase complex 31. Biomolecules that can be derived from phenylalanine include the following, except for: a). GABA b). dopamine c). DOPA d). epinephrine 32. The rate limiting step of fatty acid biosynthesis is: a). citrate cleavage b). acetyl CoA carboxylation

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00:02 Hello students for the given question 23 the correct option is d which is accumulated datp forms crystals damaging joints causing gout is not a symptom caused by adenosin d -aiminase deficiency adenosine d -aiminase is a rare genetic disorder that affects the immune system it is caused by a deficiency of the enzyme adenosine d -a -minase which is just a rare genetic disorder that affects the immune system it is caused by a deficiency of the enzyme adenocinase which is just a responsible for removing the minor group from adenocin a building block of dna the deficiency leads to the accumulation of toxic byproducts such as d atp which can inhibit the activity of other enzymes and cause damage to cells the symptoms of ada can include recurrent infections delayed growth and development and an increased risk of developing cancer in severe cases it can cause a condition called severe combined immunodeficiency in which the body is unable to amount and effective immune response to infections.

01:34 For question 24, the correct answer is d, that is, alpha -ketogloutrate can be used to synthesize glutamate and glutamine is not a correct statement about the metabolites in tca cycle.

01:55 Alpha -ketogloutrate is an important intermediate in the tca cycle and it is used in the process of oxidative decarboxilation by the enzyme alpha -ketoglutrate dehydrogenase.

02:09 Generates succinyl co -enzyme a and nadh plus h plus.

02:14 Additionally, alpha -ketoglutrate can also be converted to glutamate by the enzyme glutamate dehydrogenase, which is an important in the process of ammonia detoxification and in generation of nadph, a reducing agent required for many biosynthetic reactions.

02:32 For question 25, the correct answer is the regulatory enzyme in the biosynthesis of cholesterol is hmg coenzyme a reductase.

02:50 Hmg coenzyme a reductase catalyzes the conversion of hmg coa to mevalonate, which is the rate limiting step in the biosynthesis of cholesterol.

03:11 It is regulated by a variety of mechanisms including feedback inhibition by cholesterol and its derivatives as well as by hormones such as insulin and glucagon.

03:20 The activity of hmg coenzyme a reductase is also regulated.

03:24 By the post -translational modifications including phosphorylation and ubiquitination.

03:30 For question 26, the correct answer is d option, that is, carbon skeleton from the degradation of pyramidine is not an anaplurotic carbon source.

03:48 Anapleurotic carbon reactions are metabolic pathways that replenish the dca cycle intermediates that are removed during catalic reactions.

03:57 Anapleuratic reactions are necessary to maintain the balance of tc intermediates and to sustain the energy produced or producing processes whereas here the option a, b and c are all anaplurotic carbon sources...

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