24/50 Next? All the following are correct regarding muscarinic receptor, Except The effect of acetylcholine on these receptors (smooth muscles and glands) involve activation of Gq protein and increase Calcium ion inside the cell. The antagonist of these receptors will inhibit the heart function but activate GI motility and secretion. The effect of acetylcholine on these receptors (heart) involve activation of Gi protein and high entry of potassium ion. These receptors could be blocked by atropine
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The effect of acetylcholine on muscarinic receptors in smooth muscles and glands does involve activation of G protein and an increase in calcium ion inside the cell. This statement is correct. Show more…
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Which of the following is true about the acetylcholine receptor? a. Acetylcholine enters the cell through the channel in the receptor. b. The receptor is a gated acetylcholine channel. c. The acetylcholine receptor is a cytoplasmic receptor. d. Acetylcholine binds and causes the Na+ ion channel to open allowing Na+ to enter the cell
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18. Acetylcholine is released from many neurons in the nervous system. Acetylcholinesterase inhibitors cause activation on the postsynaptic membranes of these neurons by ________________. a. Increasing the release of acetylcholine from the neuron b. Inhibiting the reuptake of acetylcholine into the neuron c. Upregulating the number of acetylcholine receptors on the postsynaptic membrane. d. Decreasing the amount of acetylcholine destroyed in the synapse e. All of the above
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QUESTION 9 Acetylcholine acts at a GPCR on heart muscle to make the heart beat more slowly. It does so by ultimately opening K+ channels in the plasma membrane (as diagrammed in Figure Q16-32), which decreases the cell's excitability by making it harder to depolarize the plasma membrane. Indicate whether each of the following conditions would increase or decrease the effect of acetylcholine. A. Addition of a drug that stimulates the GTPase activity of the Gα subunit B. Mutations in the K+ channel that keep it closed all the time C. Modification of the Gα subunit by cholera toxin D. A mutation that decreases the affinity of the βγ complex of the G protein for the K+ channel E. A mutation in the acetylcholine receptor that prevents its localization on the cell surface F. Adding acetylcholinesterase to the external environment of the cell
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