Question

3) Given the following topogenic sequence of a multipass transmembrane protein: N ++ ++ 1 2 3 4 5 6 7 C Numbered boxes represent hydrophobic domains. ++ signs indicate positively charged amino acids next to the hydrophobic domains. A) Draw the predicted localization of this protein on the ER membrane below: Cytosol ER Membrane Lumen B) If this protein is later transported to the cell plasma membrane. Which end of the protein would end up in the extracellular side? C) What would you predict if the 1st hydrophobic domain is converted to a hydrophilic domain? Draw the predicted localization on the ER membrane below: Cytosol ER Membrane Lumen

          3) Given the following topogenic sequence of a multipass transmembrane protein:
N
++ ++
1
2
3
4
5
6
7
C
Numbered boxes represent hydrophobic domains.
++ signs indicate positively charged amino acids next to the hydrophobic domains.
A) Draw the predicted localization of this protein on the ER membrane below:
Cytosol
ER Membrane
Lumen
B) If this protein is later transported to the cell plasma membrane. Which end of the protein would end up in the extracellular side?
C) What would you predict if the 1st hydrophobic domain is converted to a hydrophilic domain?
Draw the predicted localization on the ER membrane below:
Cytosol
ER Membrane
Lumen

3) Given the following topogenic sequence of a multipass transmembrane protein:
N
++ ++
1
2
3
4
5
6
7
C
Numbered boxes represent hydrophobic domains.
++ signs indicate positively charged amino acids next to the hydrophobic domains.
A) Draw the predicted localization of this protein on the ER membrane below:
Cytosol
ER Membrane
Lumen
B) If this protein is later transported to the cell plasma membrane. Which end of the protein would end up in the extracellular side?
C) What would you predict if the 1st hydrophobic domain is converted to a hydrophilic domain?
Draw the predicted localization on the ER membrane below:
Cytosol
ER Membrane
Lumen

Added by Gregorio R.

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