4) Alternative splicing has been estimated to occur in more than 95% of multi-exon genes. Which of the following is not an evolutionary advantage of alternative splicing? a Alternative splicing increases diversity without increasing genome size. b Different gene isoforms can be expressed in different tissues. c Alternative splicing creates shorter mRNA transcripts. d Different gene isoforms can be expressed during different stages of development.
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2) Different gene isoforms can be expressed in different tissues: This statement is also true, as alternative splicing can produce tissue-specific isoforms that are only expressed in certain tissues, allowing for specialized functions in different parts of the Show more…
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Alternative splicing is present in about 90% of human genes and can explain why our 20,325 genes can encode more than 1,000,000 proteins. Examine the image below of Gene Alpha. Gene Alpha Exon #1 Intron A Exon #2 Intron B Exon #3 1. (2 pts) To create a transcript, which portions of this DNA sequence would be REMOVED during splicing? (Please be specific - ie. Exon #1, Intron A, etc.) 2. (3 pts) Gene Alpha can encode 7 different proteins! Explain how alternative splicing can lead to this phenomenon and give at least 3 specific examples of the different proteins that could be produced from Gene Alpha.
Adi S.
Alternative splicing takes place in more than $95 \%$ of the human protein-encoding genes with multiple exons. Researchers have found that how a pre-mRNA is spliced is affected by the pre-mRNA's promoter sequence (D. Auboeuf et al. $2002 .$ Science $298: 416-419$ ). In addition, factors that affect the rate of elongation by the RNA polymerase during transcription affect the type of splicing that takes place. These findings suggest that the process of transcription affects splicing. Propose one or more mechanisms that would explain how transcription might affect alternative splicing.
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