6-11. Students at the Southern Illinois University at Edwardsville used isothermal titration calorimetry to determine the enthalpy ($\Delta H^\circ = -50.3 \pm 2.2$ kJ/mol) and conditional equilibrium constant ($K' = 1.31 \pm 0.11 \times 10^5$ M$^{-1}$) (Section 8-1) for binding of the inhibitor N-acetyl glucosamine to the enzyme lysozyme at 25.0 $^\circ$C.$^{30}$ Lysozyme + inhibitor $\rightleftharpoons$ Lysozyme-inhibitor complex (a) Determine $\Delta G^\circ$ for the equilibrium. (b) Determine $\Delta S^\circ$ for the equilibrium. (c) Determine the uncertainty associated with $\Delta G^\circ$ and $\Delta S^\circ$.
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Given: Temperature, $T = 25.0^\circ\text{C}$ Enthalpy change, $\Delta H^\circ = -50.3 \pm 2.2 \text{ kJ/mol}$ Equilibrium constant, $K' = 1.31 \pm 0.11 \times 10^5 \text{ M}^{-1}$ Target variables: (a) $\Delta G^\circ$ (b) $\Delta S^\circ$ (c) Uncertainty in Show more…
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