6) 5-Bromouracil (5-Bu) is an analog of thymine that normally pairs with adenine. However, its ionized form preferentially binds with guanine. Given the DNA sequence below, what is the mutated sequence that will result after two rounds of replication if the 5-Bu was incorporated as an analog in the DNA and transitioned to ionized from before DNA replication? 5'-GTTGTG-3' 3'-CAACAC-5' A) 5'-GTTGTC-3' 3'-CAACAG-5' B) 5'-GTTGT-3' 3'-CAACA-5' C) 5'-GTTGAG-3' 3'-CAACTC-5' D) 5'-GCTGTG-3' 3'-CGACAC-5' E) 5'-GTTGTGC-3' 3'-CAACACG-5'
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5-Bu is an analog of thymine, which means it can replace thymine in DNA. Normally, thymine pairs with adenine (A-T pairing). However, when 5-Bu is ionized, it preferentially pairs with guanine (G) instead of adenine. Show more…
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7) Adenine and thymine form hydrogen bonds between them, while cytosine and guanine form bonds. A) 2, 3 B) 3, 4 C) 3, 2 D) 4, 3 Answer: 8) The idea that the adenine and thymine bases of the DNA interact in some manner was first proposed by . A) Watson and Crick B) Franklin C) Pauling D) Chargaff Answer: 9) Cells are treated with a drug that blocks purine synthesis. Which bases would not be made in those treated cells? A) cytosine, thymine, and uracil B) adenine and guanine C) adenine and thymine D) cytosine and guanine Answer: 10) Which DNA molecule form is a left-handed? A) B DNA B) Z DNA C) R DNA Answer:
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The thymine analog 5 -bromouracil is a chemical mutagen that induces single base-pair substitutions in DNA called transitions (substitutions of one purine for another purine and one pyrimidine for another pyrimidine). Using the known nature of the genetic code (Table 12.1 ), which of the following amino acid substitutions should you expect to be induced by 5 -bromouracil with the highest frequency: (a) Met $\rightarrow$ Val; (b) $\mathrm{Met} \rightarrow$ Leu; (c) Lys $\rightarrow$ Thr; (d) $\mathrm{Lys} \rightarrow \mathrm{Gln}$ (e) $\operatorname{Pro} \rightarrow$ Arg; or (f) Pro $\rightarrow$ Gln? Why?
Within the DNA double helix, nucleic acid strands run antiparallel. Shown here is a sequence on one strand of DNA. 5'GGATA3' Select the appropriate sequence that would complement the above sequence on the opposing strand. 5'UAUCC3' 5'TATCC3' 3'TATCC5' 5'CCTAT3' 5'ATAGG3'
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