6.3. Sedimentation coefficients (in Svedberg units) are often non-additive for macromolecular complexes. For example, the assembled ribosome and proteasome each have lower total sedimentation coefficients than one might expect given the constituents. How might a macromolecular assembly have a higher sedimentation coefficient than the sum of its subunits?
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The sedimentation coefficient (S) is a measure of how fast a particle sediments in a centrifugal field, typically expressed in Svedberg units (S). It depends on the mass, shape, and density of the particle, as well as the density and viscosity of the medium. Show more…
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