Phenylketonuria (PKU) is a human autosomal genetic disorder in which the affected individual cannot metabolize the amino acid phenylalanine. The disease is characterized by severe mental retardation if left untreated. The disease is caused by homozygosity for a recessive, mutant allele. If two parents are heterozygous for the allele, what is the probability that their child will have PKU?
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We know that PKU is caused by homozygosity for a recessive, mutant allele. This means that both copies of the gene must be the mutant allele for the individual to have PKU. Show more…
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Phenylketonuria (PKU) is a disease that results from a recessive gene. Suppose that two unaffected parents produce a child with PKU. a. What is the probability that a sperm from the father will contain the PKU allele? b. What is the probability that an egg from the mother will contain the PKU allele? c. What is the probability that their next child will have PKU? d. What is the probability that their next child will be heterozygous for the PKU gene?
Phenylketonuria (PKU) is a disease that results from a recessive gene. Two normal parents produce a child with PKU. a. What is the probability that a sperm from the father will contain the PKU allele? b. What is the probability that an egg from the mother will contain the PKU allele? c. What is the probability that their next child will have PKU? d. What is the probability that their next child will be heterozygous for the PKU gene?
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Consider the accompanying pedigree of a rare autosomal recessive disease, PKU. 1 ? II IV a. List the genotypes of as many of the family members as possible. b. If persons $A$ and $B$ marry, what is the probability that their first child will have PKU? c. If their first child is normal, what is the probability that their second child will have PKU? d. If their first child has the disease, what is the probability that their second child will be unaffected? (Assume that all people marrying into the pedigree lack the abnormal allele.)
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