9. Carbon monoxide (CO) is toxic to humans because: A. It Binds to myoglobin and causes it to denature. B. It is rapidly converted to toxic CO2. C. It binds to the globin portion of hemoglobin and prevents the binding of O2. D. It binds to the Fe in hemoglobin and prevents the binding of O2. E. It binds to the heme portion of hemoglobin and causes heme to unbind from hemoglobin. 10. Patients with chronic hypoxia (low O2 levels) due to decreased lung function may adapt by increasing their circulating BPG levels. Predict which outcome will be TRUE for such a patient. A. p50 for O2 will be decreased. B. p50 for O2 will be increased. C. The R-state of hemoglobin will be favored. D. O2 binding to hemoglobin will be hyperbolic. E. None of the answers is correct.
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(a) Carbon monoxide (CO) is a poisonous gas because it binds very strongly to the oxygen carrier hemoglobin in blood. A concentration of $8.00 \times 10^{2}$ ppm by volume of carbon monoxide is considered lethal to humans. Calculate the volume in liters occupied by carbon monoxide in a room that measures $17.6 \mathrm{~m}$ long, $8.80 \mathrm{~m}$ wide, and $2.64 \mathrm{~m}$ high at this concentration. (b) Prolonged exposure to mercury (Hg) vapor can cause neurological disorder and respiratory problems. For safe air quality control, the concentration of mercury vapor must be under $0.050 \mathrm{mg} / \mathrm{m}^{3}$. Convert this number to g/L. (c) The general test for type II diabetes is that the blood sugar (glucose) level should be below $120 \mathrm{mg}$ per deciliter $(\mathrm{mg} / \mathrm{dL})$. Convert this number to micrograms per milliliter ( $\mu \mathrm{g} / \mathrm{mL}$ ).
Hemoglobin (Hb) and oxygen gas form a complex (HbO2) that carries oxygen throughout the human body. Unfortunately, carbon monoxide also binds to hemoglobin so that the equilibrium shown below is established. Carbon monoxide poisoning occurs when the concentration of HbO2 in the blood is reduced. In a patient suffering from carbon monoxide poisoning, he/she is removed to an area of fresh air or administered oxygen. Select all the changes that occur in the equilibrium to restore HbO2 concentration. HbO2 + CO ⇌ HbCO + O2 [O2] is increased [O2] is decreased [CO] is increased [CO] is decreased the equilibrium shifts left the equilibrium shifts right none of these occur all of these occur
Sri K.
How does the administration of 100 percent oxygen save a patient from carbon monoxide poisoning? Why wouldn’t giving carbon dioxide work? a. At that concentration, oxygen will be transported in the body at a high rate by dissolving in blood. Oxygen has more affinity for hemoglobin than carbon dioxide. b. At that concentration, oxygen will displace the carbon monoxide from the hemoglobin. Oxygen has more affinity for hemoglobin than carbon dioxide. c. At that concentration, oxygen will displace the carbon monoxide from the hemoglobin. Carbon dioxide has more affinity for hemoglobin than oxygen. d. At that concentration, oxygen will be transported in the body at a high rate by dissolving in blood. Carbon dioxide has more affinity for hemoglobin than oxygen.
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