9. What is the role of an enzyme's allosteric site? - Binds coenzyme. - Regulates the active site. - Regulates the metal ion. - Binds substrate. 10. What cellular amount of an allosteric activator is likely needed to affect the function of an enzyme? - The amount of allosteric activator could be lower than the amount of substrate. - The amount of allosteric activator needs to be higher than the amount of substrate. 11. Which molecule represents an intermediate in the pathway below? - W - 2 - Z - Y 12. The enzymatic pathway is controlled by feedback inhibition. Based on what you learned about feedback inhibition, which answer most likely explains how feedback inhibition of this pathway works? - 3 will inhibit W - X will inhibit 2 - Z will inhibit 1 - 1 will inhibit Y
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Extra Credit: Up to 5 points. Matching A. Allosteric enzymes B. Allosteric site C. Allosteric inhibitors D. Allosteric activators E. Feedback inhibition.
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Describe allosteric regulation of enzyme activity. How does allosteric inhibition differ from other modes of regulation, and how can these work in concert to finely regulate enzyme activity? Provide an example.
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In the equation below, substrate $C$ is an allosteric inhibitor to enzyme 1. Which of the following is another mechanism necessarily caused by substrate $C ?$ $$\mathrm{A} \underset{\text { enzyme } 1}{\longrightarrow} \mathrm{B} \underset{\text { enzyme } 2}{\longrightarrow} \mathrm{C}$$ (A) Competitive inhibition (B) Irreversible inhibition (C) Feedback enhancement (D) Negative feedback
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