90 1 point Which of the following is TRUE regarding the Philadelphia chromosome? It contains the BCR-ABL fusion oncogene that has tyrosine kinase activity. It is found in most patients with chronic myeloid leukemia. It contains the BCR-ABL fusion oncogene which causes cells to divide uncontrollably. It is the result of a translocation between chromosome 9 and chromosome 22. All of the above.
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Step 1: The Philadelphia chromosome is a genetic abnormality that is found in most patients with chronic myeloid leukemia. Show more…
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Which of the following is true regarding the cause of Chronic myelogenous leukemia? (Philadelphia chromosome) The BCR/ABL fusion gene that results encodes for a protein with weak tyrosine kinase activity. It is the result of a reciprocal translocation between the long arms of chromosomes 22 and 9. Chromosomal inversion that brings together the NTRK1 gene and TPM3 gene. A cytogenetic change results in the relocation of the ABL oncogene from chromosome 9 to chromosome 22.
Sri K.
BCR-ABL fusion gene, often called the Philadelphia chromosome, is a hallmark chromosomal translocation in patients suffering from Chronic myeloid leukemia (CML). This is diagrammed below: Normal chromosomes Chromosomes MCat Changed chromosomes Changed chromosomes Chromosome Chromosome Changed chromosome Chromosome Philadelphia chromosome Chromosomal translocation Identify the phase of the cell cycle where this chromosomal translocation most likely takes place: A. G1 Phase B. S phase C. G2 phase D. M phase
Dominador T.
The chromosome $9 / 22$ translocation associated with CML (chronic myelogenous leukemia) is called the Philadelphia chromosome after the city in which its cancer association was first discovered in 1960 . People with CML do not inherit this translocation it occurs in somatic cells. Why do you think that this particular translocation that fuses the $b c r$ and $a b l$ genes happens independently in the somatic cells of many different people?
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