A 10-year-old boy is brought to the physician because of a 4-day history of nosebleeds and easy bruising. Three weeks ago, he had an upper respiratory tract infection. Physical examination shows ecchymoses over the upper and lower extremities. Laboratory studies show a hemoglobin concentration and leukocyte count within the reference ranges and a decreased platelet count. A bone marrow smear shows an increased number of megakaryocytes. Which of the following platelet abnormalities is the most likely cause of the findings in this patient? A) Antibodies directed against the glycoprotein (Gp) IIb/Illa complex 8) Decreased binding of Gpla/lla (a8,) to collagen C) Decreased concentration of the Gp1b/IX complex D) Decreased concentration of the Gplib/Illa complex E) Decreased synthesis of thromboxane A, F) Deficient binding of von Willebrand factor to the Go1b/IX complex
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The patient is a 10-year-old boy with a recent history of an upper respiratory tract infection, now presenting with nosebleeds (epistaxis) and easy bruising (ecchymoses). These symptoms suggest a bleeding disorder, which could be due to abnormalities in blood Show more…
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