A 17-year-old boy with pneumonia undergoes serologic testing by ELISA for Mycoplasma pneumonia infection. The test is performed as follows (washing occurs between each step): Step Addition to Well 1 M. pneumonia antigens (allowed to coat wells) 2 patient serum 3 goat antihuman IgG conjugated to horseradish peroxidase 4 TMB (substrate for horseradish peroxidase) The test is done twice: once on a specimen collected at the initial visit to the physician's office, and once on a specimen collected 14 days later. No color development is seen with the first specimen, but color development is seen with the second specimen. Which of the following is the most likely explanation for these results? A) The patient had a primary infection with M. pneumoniae at the time of the first office visit B) The patient was infected with M. pneumoniae at some point during the 14-day interval between the collection of the first and second specimens C) The patient was previously infected with M. pneumonia but is not currently infected with this organism D) The patient was previously infected with M. pneumonia but was reinfected within the past month E) No conclusions can be drawn until the results of testing for M. pneumonia IgM are known
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Microbiology II Case Study – Primary Atypical Pneumonia in a Child A 12-year-old girl was admitted with fever, a persistent nonproductive cough, and night sweats; she appeared mildly dyspneic. Four weeks previously, the patient had been well. During the course of illness, she experienced episodic pain in the subscapular region and shoulder. On admission her vital signs were: temperature - 38.5°C; pulse 98/min; respirations - 29/min; and blood pressure - 125/65 mm Hg. Other laboratory tests indicated a leukocyte count of 6.3 x 10^9/L, white blood cell populations within normal limits, an increased blood sedimentation rate and a high value for C-reactive protein. Chest radiographs showed bilateral lower lobe involvement. Blood cultures were negative and routine cultures of bronchial washings revealed no pathogens. An immunoblot for anti-I IgM was strongly positive and a complement fixation assay gave a serum antibody titer of >1:512 using M. pneumoniae antigen. Oral erythromycin and intravenous cefuroxime were administered. The patient turned afebrile within 2 days; improvement was slow, but uneventful. She was discharged from the hospital 5 days after admission.
Adi S.
4. A healthy 20-year-old young adult was diagnosed with pneumonia. Physician decided that his case was very mild that he just needed to rest and to drink a lot of water. His physician told him that he might have a walking pneumonia. What is the most possible type of pneumonia that he contracted and why? A. Pneumococcal pneumonia; the causative agent doesn't destroy lung tissue and it can be treated with antibiotics. He probably also received a vaccine against it when he was a kid. B. Mycoplasmal pneumonia; this type of pneumonia causes the mildest signs and symptoms and it is a common pneumonia in college students. C. Viral pneumonia; there are many antiviral medications that can be given for this type of pneumonia and are effective, with very few side effects D. Klebsiella pneumonia; this disease can easily be treated with antibiotics, and has the shortest recovery time. E. Fungal pneumonia; these types of pneumonia are chronic, remain latent, and are easily treated with antifungal medications in the majority of patients.
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