A 19-year-old male is being evaluated for muscle weakness. Evaluation of a muscle biopsy revealed normal rates of succinate oxidation but very low rates of pyruvate oxidation. Further testing determined normal levels of enzymatic activity in both malate dehydrogenase and pyruvate dehydrogenase. Based on this data, the patient may have a mutation in a gene encoding for which mitochondrial protein? Complex I (NADH Q-oxidoreductase) Complex II (Succinate Q-reductase) Complex III (Q-cyt c oxidoreductase) Complex IV (Cytochrome oxidase) Complex V (ATP synthase)
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The patient has muscle weakness, which suggests a problem in energy production (ATP synthesis). Show more…
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Supreeta N.
Muscle cells need energy to contract. One biochemical pathway for energy transfer is the breakdown of glucose to pyruvate in a process called glycolysis. In the presence of sufficient oxygen in the cell, pyruvate is oxidized to CO2 and H2O to make further energy available. However, under extreme conditions, not enough oxygen can be supplied to the cells, so muscle cells produce lactate ion according to the reaction where ΔrG°' = -25.1 kJ/mol. In living cells, the pH value is about 7. The hydronium ion concentration is constant and is included in ΔG°, which is then called ΔrG°'. Calculate ΔrG° for the reaction at 25 °C.
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