Question

A. (2 pts) Which channel (alpha1Z or alpha 2Z) has a greater probability of inactivation? Are these channels more or less likely to inactivate as the concentration of glycine increases? B. (1 pt) Which channel is more likely to be inactivated by the UV-activated form of Azo-NZ1? Texts: Question 4 (3 pts): The study below is characterizing a novel tool, azobenzene-nitrazepam (Azo-NZ1), for studying glycine receptor conductance. Azo-NZ1 can change its molecular/structural conformation when exposed to UV. The response to two different types of channels, those containing alpha1 subunits versus those containing alpha2 subunits, is shown on the left and right respectively. Application of Azo-NZ1 to the bath solution is indicated by the labeled horizontal line, while UV-triggered conformation switch is indicated by the purple bar. A alpha1Z GlyRs Glycine 20uM B A alpha 2Z GlyRs Glycine 50M B Glycine 300M Glycine 300M 200pA 400pA 5sec 5sec 5sec 200pA Azo-NZ1 50M 5sec Azo-NZ1 50M Azo-NZ1 50M Azo-NZ1 50M Maleeva et al, eNeuro (2021) A. (2 pts) Which channel (alpha1Z or alpha 2Z) has a greater probability of inactivation? Are these channels more or less likely to inactivate as the concentration of glycine increases? B. (1 pt) Which channel is more likely to be inactivated by the UV-activated form of Azo-NZ1?

          A. (2 pts) Which channel (alpha1Z or alpha 2Z) has a greater probability of inactivation? Are these channels more or less likely to inactivate as the concentration of glycine increases?

B. (1 pt) Which channel is more likely to be inactivated by the UV-activated form of Azo-NZ1?

Texts: 

Question 4 (3 pts): The study below is characterizing a novel tool, azobenzene-nitrazepam (Azo-NZ1), for studying glycine receptor conductance. Azo-NZ1 can change its molecular/structural conformation when exposed to UV. The response to two different types of channels, those containing alpha1 subunits versus those containing alpha2 subunits, is shown on the left and right respectively. Application of Azo-NZ1 to the bath solution is indicated by the labeled horizontal line, while UV-triggered conformation switch is indicated by the purple bar.

A alpha1Z GlyRs Glycine 20uM
B

A alpha 2Z GlyRs Glycine 50M
B Glycine 300M
Glycine 300M
200pA
400pA
5sec
5sec
5sec
200pA
Azo-NZ1 50M
5sec Azo-NZ1 50M
Azo-NZ1 50M
Azo-NZ1 50M
Maleeva et al, eNeuro (2021)

A. (2 pts) Which channel (alpha1Z or alpha 2Z) has a greater probability of inactivation? Are these channels more or less likely to inactivate as the concentration of glycine increases?

B. (1 pt) Which channel is more likely to be inactivated by the UV-activated form of Azo-NZ1?

a 2 pts which channel alpha1z or alpha 2z has a greater probability of inactivation are these channels more or less likely to inactivate as the concentration of glycine increases b 1 pt whic 84467

Added by James B.

Question

Please give Ace some feedback