Question

A 22-year-old woman is brought to the emergency department because of a 2-day history of upper respiratory tract symptoms and a 1-day history of fever, headache, and stiff neck. She was admitted to the hospital at the age of 17 years for treatment of meningococcemia, from which she recovered without complications. Her temperature is 39°C (102.2ºF). Physical examination shows nuchal rigidity. Lumbar puncture shows cloudy cerebrospinal fluid (CSF), and a Gram stain of CSF shows gram-negative diplococci. A deficiency of which of the following is the most likely explanation for her recurrent systemic infection? A) Complement B) Natural killer cell function C) Neutrophil number D) Secretory IgA E) T-lymphocyte function

          A 22-year-old woman is brought to the emergency department because of a 2-day history of upper respiratory tract symptoms and a 1-day history of fever, headache, and stiff neck. She was admitted to the hospital at the age of 17 years for treatment of meningococcemia, from which she recovered without complications. Her temperature is 39°C (102.2ºF). Physical examination shows nuchal rigidity. Lumbar puncture shows cloudy cerebrospinal fluid (CSF), and a Gram stain of CSF shows gram-negative diplococci. A deficiency of which of the following is the most likely explanation for her recurrent systemic infection?
A) Complement
B) Natural killer cell function
C) Neutrophil number
D) Secretory IgA
E) T-lymphocyte function

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