A 32-year-old woman is brought to the emergency department because of a 1-hour history of severe shortness of breath and wheezing. Three hours ago, she took naproxen for a headache. She has a history of severe bronchoconstriction 2 years ago after taking aspirin. She also has intermittent asthma, sinusitis, and nasal polyps. Her respirations are 15/min. Physical examination shows nasal polyps and anosmia. Induction of which of the following is the most likely cause of this patient's current condition? A) Binding of acetylcholine to muscarinic receptors of the airway B) IgE binding to mast cells and basophils C) 5-Lipoxygenase pathway and synthesis of leukotrienes D) Phospholipase A2 and downstream chemical mediators E) Phosphodiesterase and adenosine receptors
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These symptoms suggest that she may have aspirin-exacerbated respiratory disease (AERD), also known as Samter's triad. In this condition, taking nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin or naproxen can trigger severe bronchoconstriction and Show more…
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