Question

A 40-year-old man comes to the physician because of a 1-year history of a chronic scaly rash. He has a history of similar rashes, but they have occurred intermittently. He says that he sometimes picks off the scales of the rash, which causes mild bleeding. Physical examination shows the findings in the photograph. Microscopic examination of one of the lesions shows the separation of individual epidermal keratinocytes from neighboring cells. The most likely underlying cause of these findings is disruption of which of the following junctional complexes? A) Desmosomes (maculae adherentes) B) Focal adhesions C) Gap junctions D) Hemidesmosomes

          A 40-year-old man comes to the physician because of a 1-year history of a chronic scaly rash. He has a history of similar rashes, but they have occurred intermittently. He says that he sometimes picks off the scales of the rash, which causes mild bleeding. Physical examination shows the findings in the photograph. Microscopic examination of one of the lesions shows the separation of individual epidermal keratinocytes from neighboring cells. The most likely underlying cause of these findings is disruption of which of the following junctional complexes?
A) Desmosomes (maculae adherentes)
B) Focal adhesions
C) Gap junctions
D) Hemidesmosomes

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