Question

A 42-year-old man comes to the emergency department because of a 3-day history of left-sided flank pain and a 3-month history of severe swelling of his legs. He has no history of serious illness. He is 178 cm (5 ft 10 in) and weighs 76 kg (168 Ib); BMI is 24 kg/m?. Blood pressure is 125/80 mm Hg; all other vital signs are within normal limits. Physical examination discloses tenderness to palpation over the left flank and 3+ edema of the lower extremities. Urinalysis is negative for blood and shows 4+ protein. CT scan of the abdomen shows a thrombosis of the left renal vein. If a renal biopsy specimen were obtained in this patient, it would most likely show which of the following findings: A) Amyloid deposition B) Anti-glomerular basement membrane antibody deposition C) IgA deposition D) Segmental areas of mesangial sclerosis E) Thickening of basement membrane

          A 42-year-old man comes to the emergency department because of a 3-day history of left-sided flank pain and a 3-month history of severe swelling of his legs. He has no history of serious illness. He is 178 cm (5 ft 10 in) and weighs 76 kg (168 Ib); BMI is 24 kg/m?. Blood pressure is 125/80 mm Hg; all other vital signs are within normal limits. Physical examination discloses tenderness to palpation over the left flank and 3+ edema of the lower extremities. Urinalysis is negative for blood and shows 4+ protein. CT scan of the abdomen shows a thrombosis of the left renal vein. If a renal biopsy specimen were obtained in this patient, it would most likely show which of the following findings:
A) Amyloid deposition
B) Anti-glomerular basement membrane antibody deposition
C) IgA deposition
D) Segmental areas of mesangial sclerosis
E) Thickening of basement membrane

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