A 47-year-old man has a lung carcinoma with metastases. He receives chemotherapy. A month later, histologic examination of a metastatic lesion shows many foci in which individual tumor cells appear shrunken and deeply eosinophilic. Their nuclei exhibit condensed aggregates of chromatin under the nuclear membrane. The pathologic process affecting these shrunken tumor cells is most likely triggered by release of which of the following substances into the cytosol? a. Cytochrome c b. Catalase C. BCL2 d. Lipofuscin
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The description of tumor cells being shrunken, deeply eosinophilic, and having condensed chromatin aggregates under the nuclear membrane is characteristic of apoptosis. Show more…
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