A 49-year-old obese man recently diagnosed with vasospastic angina started a treatment with nifedipine. The drug has a volume of distribution (Vd) of 55 L in a 70-kg person, but in this obese patient, the Vd turned out to be 110 L. The standard loading dose of nifedipine for a patient weighing 70 kg is 30 mg. Which of the following should be the therapeutic loading dose administered to this patient (in mg) in order to achieve the same target concentration? a. 120 mg b. 90 mg c. 20 mg d. 60 mg e. 30 mg
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- Volume of distribution (Vd) is a pharmacokinetic parameter that relates the amount of drug in the body to the concentration of the drug in the blood or plasma. It is used to determine the loading dose of a drug needed to achieve a desired plasma concentration. Show more…
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