A 57-year-old woman requires intubation in the intensive care unit after developing progressive dyspnea and hypoxemia 45 minutes after the initiation of a transfusion of packed red blood cells. The patient has cirrhosis and was admitted to the hospital because of melena; the transfusion was initiated after she was found to have a hemoglobin concentration of 6.4 g/dL. Medical history includes hepatitis C diagnosed at the age of 41 years. She has a 25-year history of illicit intravenous drug use. The patient is intubated and sedated. Her temperature is 36.9°C (98.4°F), pulse is 92/min, respirations are 16/min, and blood pressure is 94/58 mm Hg. There is no jugular venous distention. Bilateral basilar crackles are heard on inspiration; there are no wheezes. Physical examination shows spider angiomata on the chest and abdomen, minimal ascites, and trace bilateral pedal edema. Chest x-ray shows bilateral diffuse airspace disease without pleural effusions or cardiomegaly. This patient most likely developed which of the following types of transfusion reactions? • A) Acute hemolytic reaction • B) Acute lung injury • C) Anaphylactic reaction • D Rh incompatibility E) Serum sickness