A client has been admitted for a tensilon test Shortly after the administration of edrophonium, the client reports that his muscle strength is significantly weaker than before the test. The nurse recognizes that this finding supports what diagnosis? Alzheimer's Disease Parkinson's Disease Myasthenic crisis Cholinergic
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Edrophonium, the drug used in the test, temporarily improves muscle strength in people with Myasthenia Gravis. However, in this case, the client reports that his muscle strength is significantly weaker after the administration of edrophonium. This could indicate a Show more…
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You are a teaching physician working at a hospital. Your patient is a 30 year old who has been suffering from weak muscles. Lately they have been having difficulty breathing and swallowing. After a blood test, you confirm that the patient is suffering from Myasthenia Gravis, which occurs when the immune system targets the acetylcholine receptors on the muscle sarcolemma reducing the number of receptors. You prescribe the patient Pyridostigmine, which is a molecule that inhibits acetylcholine esterase (the enzyme that breaks down acetylcholine). You ask a resident physician to explain the diagnosis and the prescription. Here is the student's response: 1. Myasthenia Gravis is an autoimmune disease that targets the acetylcholine receptors on your muscle cells. and produce movement. 3. With reduced numbers of functional acetylcholine receptors available your muscles contract continuously, leading to muscle weakness due to muscle fatigue. 4. This muscle weakness is particularly noticeable in muscles that are used frequently, such as those controlling breathing and swallowing. 5. Normally, after acetylcholine causes a muscle contraction, it's broken down by an enzyme called acetylcholinesterase. 6. In the case of Myasthenia Gravis we want to reduce the action of acetylcholine to give it less time to bind to the available receptors and reduce the chance of muscle contraction. 7. Pyridostigmine decreases the breakdown of acetylcholine, reducing its concentration in the space between the nerve and muscle cells. 8. This decreased level of acetylcholine improves the likelihood of it binding to the remaining functional receptors, thereby reducing muscle contraction and strength. Choose the answers that are incorrect in the resident physician's explanation.
Bryan V.
You are a teaching physician working at a hospital. Your patient is a 30 year old who has been suffering from weak muscles. Lately they have been having difficulty breathing and swallowing. After a blood test, you confirm that the patient is suffering from Myasthenia Gravis, which occurs when the immune system targets the acetylcholine receptors on the muscle sarcolemma reducing the number of receptors. You prescribe the patient Pyridostigmine, which is a molecule that inhibits acetylcholine esterase (the enzyme that breaks down acetylcholine). You ask a resident physician to explain the diagnosis and the prescription. Here is the student's response: 1. Myasthenia Gravis is an autoimmune disease that targets the acetylcholine receptors on your muscle cells. 2. When acetylcholine binds to these receptors on the muscle cells it causes them to contract and produce movement. 3. With reduced numbers of functional acetylcholine receptors available your muscles contract continuously, leading to muscle weakness due to muscle fatigue. 4. This muscle weakness is particularly noticeable in muscles that are used frequently, such as those controlling breathing and swallowing. 5. Normally, after acetylcholine causes a muscle contraction, it's broken down by an enzyme called acetylcholinesterase. 6. In the case of Myasthenia Gravis we want to reduce the action of acetylcholine to give it less time to bind to the available receptors and reduce the chance of muscle contraction. 7. Pyridostigmine decreases the breakdown of acetylcholine, reducing its concentration in the space between the nerve and muscle cells. 8. This decreased level of acetylcholine improves the likelihood of it binding to the remaining functional receptors, thereby reducing muscle contraction and strength. Choose the answers that are incorrect in the resident physician's explanation.
If the amount of acetylcholinesterase, an enzyme that breaks down acetylcholine, is increased, which of the following would likely be the result? (A) Weakness of muscle movements (B) Excessive pain or discomfort (C) Mood swings and mood instability (D) Auditory and visual hallucinations
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