a) A COPII vesicle sorting signal on a membrane protein destined for transport from the ER to the Golgi functions by binding ________________________. b) Luminal proteins requires a ________________________ for packaging into a COPII vesicle via recognition by a ________________________. c) The -KDEL sequence functions as an luminal ER retrieval signal via its recognition by the ________________________, targeting ‘escaped’ ER luminal proteins for packaging into a __________ vesicle. d) The -KKXX sequence functions as a membrane protein ER retrieval signal via its recognition by components of the __________ vesicle coat which facilitates transport from the __________________. e) A KDEL receptor would be expected to have which two of the three sequences mentioned above? f) Which of the three targeting sequences mentioned above, -KDEL, -KKXX, or the COPII sorting signal will we expect the ER chaperone BiP to have?
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A COPII vesicle sorting signal is needed for transport from the ER to the Golgi. Show more…
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The KDEL receptor must shuttle back and forth between the ER and the Golgi apparatus to accomplish its task of ensuring that soluble ER proteins are retained in the ER lumen. In which compartment does the KDEL receptor bind its ligands more tightly? In which compartment does it bind its ligands more weakly? What is thought to be the basis for its different binding affinities in the two compartments? If you were designing the system, in which compartment would you have the highest concentration of KDEL receptor? Would you predict that the KDEL receptor, which is a transmembrane protein, would itself possess an ER retrieval signal?
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