00:01
So this condition that they're talking about is a genetic condition called alpha -5 reductase deficiency.
00:07
And as the question explains, they have small prostate glands because of this feminization.
00:19
So how would you treat someone who has prosthetic hypertrophy? so too big.
00:27
So hypertrophy is like the...
00:32
Increased size, right? it'll be increased in size, so up in size, whereas we know that people with alpha -5 reductase deficiency, they have an issue where its prostate is decreased in size.
00:54
Okay, so how would this information help one another? so a simple way to think of it is that if you don't have this alpha -5 reductase, you have less sizable prostate glands.
01:11
So if someone has hypertrophy of their prostate gland, we would want to stop the action of alpha -5 reductase.
01:20
We would want to make that deficient.
01:23
So the way that you would do that, let me see if i can, okay, moving down here so i can get a clean slate here, is by an enzyme called phanastoride.
01:40
And i'll draw its structure here.
01:43
So let me move down a little further, actually.
01:50
There we go.
01:51
Okay.
01:53
So phanasteride, it has a whole lot of rings, so it might take me a second here.
02:01
This is a, it's like an analog of the dye, hydrotestosterone, which is talked about in this question.
02:12
It's important in the creation, or it's important for testosterone, basically.
02:24
And this is going to take me a while to do this.
02:29
But it can be the inhibitor.
02:37
This is ugly, i know.
02:39
It can inhibit the 5 alpha reductase...