A mutant strain of E. coli has been identified that has both a gain of function mutation of helicase that doubles its activity and a loss of function mutation in DNA gyrase that reduces its affinity for DNA. Explain the impact, if any, on the rate of DNA replication in this bacterial strain.
Added by Jay B.
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Helicase is an enzyme that unwinds the DNA double helix, making the two strands accessible for replication. DNA gyrase, on the other hand, is a type of topoisomerase that relieves the supercoiling tension that is created ahead of the replication fork as the DNA is Show more…
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