4. A patient is exposed to a toxic compound that increases...

4. A patient is exposed to a toxic compound that increases the permeability of mitochondrial membranes to protons. Which of he following metabolic changes would be expected in this scenario? 1. Increased ATP levels 2. Increased oxygen utilization 3. Increased ATP synthetase activity 4 Decreased PDH activity

Transcript

00:01 This question relates to the way that the mitochondrial membrane is going to play a role in the electron transport chain and ultimately atp synthesis.

00:10 So as we know, we have within our mitochondria, we know that the mitochondria itself is going to be, it will consist of two membranes, an outer membrane and the inner membrane.

00:23 But if we look at the inner membrane and we are to draw it out as so, we find that what happens is, inside the mitochondria, the very interior portion of the mitochondria, we are going to find that a concentration gradient is going to build up.

00:43 And specifically, we are going to pump hydrogen's, positive hydrogen ions, out of the very inner portion of the mitochondria through this inner membrane into the layer that is going to be between the inner membrane and the outer.

01:06 Membrane.

01:07 All right.

01:07 So we are able to do this, this pumping of the hydrogen ions across the inner mitochondrial membrane by the action of the electron transport chain.

01:20 And we know that we are going to have these three coenzymes within the inner mitochondrial membrane.

01:32 We have number one, we have number three and number four.

01:37 And we also have number two, but this is not going to play a role in the electron transport chain.

01:42 So essentially, we are going to have electrons move from one electron carrier to the next.

01:53 And via this movement, we are pumping out hydrogen ions across the membrane.

02:02 Okay? these are hydrogen ions.

02:05 Now, the question here is, though, what is going to happen if this intermiticondyl membrane is going to be more permeable to hydrogen ions? well, what we have here right now is a hydrogen ion or proton gradient, where, of course, we are going to have a high concentration of h plus on this side and a low concentration on this side...

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