A person has glutamate in their cells, and they are able to make alpha-ketoglutarate from it. They are also able to make succinyl coA, succinate, fumarate, malate, and oxaloacetate. What they cannot do is produce citrate synthase. What is true for this person?
they cannot run the Krebs cycle at all
they can run the entire Krebs cycle, because as long as you have the other enzymes you don't need citrate synthase
they can do Functional Splitting of the Krebs cycle, in that they can do the first half but not the second half. Because of this they can still make FADH2, but they cannot make NADH or ATP
they can do Functional Splitting of the Krebs cycle, in that they can do the second half but not the first half. Because of this they can still make one NADH and 2 ATP, but they cannot make FADH2
An elderly patient presents with problems in motor function. Tests show that they have an increase in succinate dehydrogenase and transketolase activity in the basal nuclei, along with an inability to process FADH2 and a decrease in pyruvate dehydrogenase and aconitase. What is your diagnosis?
Huntington Disease, which is autosomal dominant and affects mainly the basal nuclei
Huntington Disease, which is autosomal recessive and affects the entire brain equally
a functional splitting of the Krebs cycle leading to a buildup of acetyl coA that affects the hippocampus
problems with the glycerol phosphate shuttle leading to a decrease in FADH2 transportation into the mitochondria
Shunts from the Krebs cycle and glycolysis can lead to (choose all that apply).
keto acid production and lipolysis (which reactions occur depend on concentrations of enzymes and the availability of substrates)
keto acid production and lipolysis (which reactions occur depend on a circadian rhythm that determines which metabolic activity occurs at which time).
gluconeogenesis, glygogenesis, fatty acid synthesis, the pentose phosphate shunt, and amino acid metabolism (which reactions occur depend on concentrations of enzymes and the availability of substrates)
gluconeogenesis, glygogenesis, fatty acid synthesis, the pentose phosphate shunt, and amino acid metabolism (which reactions occur depend on a circadian rhythm that determines which metabolic activity occurs at which time).