A phenotypically abnormal individual has a phenotypically normal father with one abnormal copy of chromosome 7 and a normal mother without any changes in chromosome structure. The order of genes along chromosome 7 in the father is as follows: RTD M centromere PU XZC (normal 7) RTD UP centromere M XZC (abnormal 7) The phenotypically abnormal offspring has a chromosome 7 with the following order of genes: RTD M centromere PU DTR How was this chromosome formed?
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A phenotypically abnormal individual has a phenotypically normal father with an inversion on one copy of chromosome 7 and a normal mother without any changes in chromosome structure. The order of genes along chromosome 7 in the father is as follows: R T D M centromere P U X Z C (normal chromosome 7) R T D U P centromere M X Z C (inverted chromosome 7) The phenotypically abnormal offspring has a chromosome 7 with the following order of genes: R T D M centromere P U D T R With a sketch (complete), explain how the abnormal chromosome was formed. In your answer, explain where the crossover occurred (i.e., between which two genes). Also, give any other products that might have been formed as a result of the crossover you described. Assume that crossing over does not occur at the centromere.
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chromosomal woman who sought genetic counseling is found to be heterozygous for a rearrangement between the second and third chromosomes Her chromosomes compared to those in a normal karyotype are shown below: What kind of chromosomal aberration is shown? Using a drawing, demonstrate how these chromosomes would pair during meiosis. Be sure to label the different segments of the chromosomes. This woman is phenotypically normal. Does this surprise you? Why or why not? Under what circumstances might you expect a phenotypic effect of such a rearrangement?
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