A prescription is received for an ophthalmic solution with a...

A prescription is received for an ophthalmic solution with a shelf life of 3 hours at room temperature (25 0 C). The preparation is to be administered in a physician’s office at 6:00 in the evening of the next day. Can the solution be prepared the evening before at 8:00 pm and still retain at least 90% of its potency (shelf life) if stored in a refrigerator?

A compounded drug suspension at a concentration of 10 mg/mL has a shelf life of 24 days when stored at 4°C. Your patient notes that she took 5 mL as prescribed immediately after she picked up the prescription at 9 a.m., then left the container in her car for three hours at 33°C while she went grocery shopping. She then put it back in the fridge and took another 5 mL as prescribed at 9 a.m. the next day. The drug hydrolyzes by zero order processes. The therapeutic range is 3-10 mg/L, VD=10 L, and oral bioavailability is 80% for this drug. a.) How much has the shelf-life been reduced by this mistake? b.) What dose did she ingest the first day and how much was absorbed? c.) What is her plasma drug concentration after the first dose? Is she in the therapeutic range? d.) What dose did she ingest at 9 a.m. the second day if the drug degrades by first order processes?

Madhur L.

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