A subset of breast cancers overexpress the receptor tyrosine kinase (RTK), known as human epidermal growth factor receptor 2 (HER2). Patients with HER2-positive breast cancers often benefit from treatment with a HER2-binding antibody known as Pertuzumab. Given that antibodies are large proteins that cannot cross the cell membrane, what might be directly impacted by Pertuzumab to limit cell proliferation? Choose one: A. Pertuzumab prevents adaptor protein binding to activated receptors. B. Pertuzumab prevents receptor coupling to G proteins. C. Pertuzumab prevents receptor dimerization. D. Pertuzumab prevents changes in gene expression by preventing transcription factor phosphorylation.
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Step 1: Pertuzumab is an antibody that binds to the receptor tyrosine kinase (RTK) known as human epidermal growth factor receptor 2 (HER2). Show more…
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