A woman who sought genetic counseling is found to be heterozygous for a chromosomal rearrangement between the second and third chromosomes. Her chromosomes, compared to those in a normal karyotype, are diagrammed below: A E A E B F B F C C G G D D H H 2 2/3 2/3 3 Part D Under what circumstances might you expect a phenotypic effect of such a rearrangement? Select the two correct statements. Translocated chromosomal material is essential in fetus birth. Translocation breakpoints occur within the genes. Translocated chromosomal material is essential in sexual differentiation. Functioning of the translocated genes depends on their neighboring genes. Translocated chromosomal material contains mostly dominant alleles.
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- The woman is heterozygous for a chromosomal rearrangement between the second and third chromosomes. This means she has one normal set of chromosomes and one set with a rearrangement. Show more…
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The chromosomes of an individual who is heterozygous for a rearrangement are diagrammed below, where the chromosomal regions are represented by letters A-F and the centromere is represented by the letter O: wild-type: A B C D E F O rearrangement: A D C B E F O A. What is the specific term for the type of chromosomal rearrangement shown? B. If a crossover event occurs between regions C and D in two non-sister chromatids, what would the chromosomes look like at the end of meiosis? Specify the order of genes along each chromosome, as well as the centromere (use the letter O to signify the centromere). Clearly identify the parental and recombinant chromosomes, describe any chromosomal mutations, including effects on the centromeres, and specify if gametes containing each chromosome would be viable or inviable.
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1. Which kind of chromosomal rearrangement always results in a loss of some genetic material? A. Duplication. B. Inversion. C. Translocation. D. Deletion. 2. What is a common repair strategy to re-align misaligned chromosomes? A. Duplication of one of the chromosomes to replace the misaligned one. B. Formation of a loop. C. Delete the misaligned portion. D. Exchange the misaligned segments with aligned segments. 3. A Robertsonian Translocation results in: A. One fragmented chromosome. B. Down Syndrome. C. One large metacentric chromosome. D. All of these choices are correct. 4. In a Robertsonian Translocation, the formation of viable gametes depends on: A. Homologous chromosomes forming a cross-like structure. B. None of these choices is correct. C. Whether Prophase I was started. D. How the chromosomes separate. 5. Generally, how do translocation and crossover differ? A. Translocation occurs in Anaphase I, whereas crossing-over occurs in Prophase I. B. All of these choices are correct. C. Translocation is only non-reciprocal, whereas crossing-over is only reciprocal. D. Translocation is the movement of genetic material between nonhomologous chromosomes, whereas crossing-over occurs between homologous chromosomes.
Josee P.
A female child inherits one X chromosome from her mother and one from her father. What sex chromosome does a male child inherit from each of his parents? Solve here! 10. Nondisjunction may occur during a. Mitosis b. Meiosis c. Fertilization d. Both a and b 11. Nondisjunction can result in a. Duplications b. Aneuploidy c. Crossing over d. Pleiotropy 12. Nondisjunction may occur during a. Anaphase 1 b. Telophase 1 c. Anaphase 2 d. a or c 13. Klinefelter syndrome (XXY) can be easily diagnosed by a. Pedigree analysis b. Aneuploidy c. Karyotyping d. Phenotypic treatment
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