Acetylcholinesterase inhibitors have therapeutic value in the treatment of some medical conditions and diseases. Which of the following do you think would be a clinical application of these drugs? View Available Hint(s) Muscular dystrophy, a genetic disease that results in abnormal muscle proteins and causes a loss of muscle mass. Myasthenia gravis, a disease in which the ACh receptors are damaged and the muscle becomes progressively weaker. Cosmetic treatment of wrinkles and frown lines. Polio, a disease in which motor neurons are attacked and damaged.
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Step 1: Acetylcholinesterase inhibitors prevent the breakdown of acetylcholine (ACh), increasing the amount of ACh available in the synapse. Show more…
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One treatment for myasthenia gravis is a medication that blocks the activity of acetylcholinesterase. Suggest why this might be a successful treatment.
Adi S.
A rare (hypothetical) genetic disease causes the body to produce antibodies that compete with acetylcholine for receptors on the motor end plate. Patients with this disease exhibit varying degrees of muscle weakness and flaccid paralysis in the affected muscles. If you could administer a drug that inhibits acetylcholinesterase or a drug that inhibits acetylcholine, which would you use to alleviate these symptoms?
Cats, dogs, and humans may develop my asthenia gravis, an autoimmune disease in which antibodies develop against acetylcholine receptors in the synapses between neurons and skeletal muscle fibers. Based on what you know of the biochemistry of muscle contraction (see Section 43.1 ), explain why people with this disease typically experience severe fatigue with even small levels of exertion, drooping of facial muscles, and trouble keeping their eyelids open.
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